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We next determined the profile and the polarity of inflammatory cytokines produced by contaminated Calu-three cells and investigated how these virally induced epithelial cytokines would affect the intrinsic features of Mφ and DC. Here, we present that Calu-3 cells responded to SARS-CoV infection by secreting several inflammatory cytokines, including interleukin-6 (IL-6), IL-eight and gamma interferon (IFN-γ)-inducible protein 10 (IP-10), in a delayed and dose-dependent manner.
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